一、团队带头人

李玲，女，华中科技大学生命科学与技术学院生物制药工程专业博士，湖北科技学院副教授，硕士生导师。主要从事生物医药材料和肝癌介入治疗的研究。主持国自然基金青年项目1项、省自然基金面上项目1项，校级创新团队1项，其它校级项目8项；参与重大研发项目2项，国家/省自然基金6项，省厅级项目4项。以第一作者或通讯作者发表论文30余篇，其中7篇SCI论文IF>10，单篇SCI论文最高影响因子20.72；授权国内发明专利3项，国际发明专利1项，申报国内发明专利6项。2021年被广东粤港澳大湾区国家纳米科技创新研究院外聘为临床专家。2022年湖北科技学院“百名优秀人才选拔计划”B类人才。同时持有临床执业医师资格证、大型医疗仪器上岗证等临床专业证书。

二、科研团队简介

团队成员分别毕业于东南大学、华中科技大学、华南理工大学及深圳大学等国内知名高校，均具备扎实的科研基础。本团队骨干成员共发表IF:10分以上高水平论文8篇，并具有参加重大研发计划项目、国家自然科学基金项目、省厅级科研项目及教学教研项目的经验，横向支持经费450余万元。具备了研究方法、技术、应用方面的研究基础，团队协作精神、科研能力、学术水平已经形成，奠定了在肿瘤诊断、治疗及创伤修复方面的技术及应用研究领域湖北省内乃至国内同行研究中的学术地位，形成鲜明特色，在湖北省同类院校中处于先进水平。

三、主要研究方向

研究领域：

(1)双模态显影温敏Pickering乳液肝癌介入治疗；

(2)射频响应性温敏纳米凝胶精准协同治疗；

(3自显影型微球栓塞剂肝动脉栓塞治疗；

(4)超声引导温敏Pickering乳液肝癌介入治疗；

(5)多孔生物基敷料止血抗菌水凝胶性能评价；

(6)柔性超透明抗菌多孔复合膜止血性能；

(7)高韧性透明自愈合PAM/SF复合水凝胶膜快速止血研究。

四、主要研究成果

1、科研项目

2、科研论文

1)Ling Li, Yanyan Cao, Haining Zhang, Min Zheng, Jun Xing, Chuansheng Zheng, Yanbing Zhao and Xiangliang Yang, Temperature sensitive nanogel-stabilized pickering emulsion of fuoroalkane for ultrasound guiding vascular embolization therapy. Journal of Nanobiotechnology.2023,(第一通讯作者，中科院分区一区，10.2)

2)Houqiang Yu, Shuanghua Zheng, Cai Wang, Jun Xing and Ling Li*，Novel Anti-VEGFR2 Antibody Conjugated Nanobubbles for Targeted Ultrasound Molecular Imaging in a Rabbit VX2 Hepatic Tumor Model. Journal of Materials Chemistry B, 2023(第一通讯作者，中科院分区二区，7.5)

3)Ling Li, Hongsen Zhang, Hao Zhao, Dingwen Shi, Chuansheng Zheng*, Yanbing Zhao*, Xiangliang Yang. Radiofrequency-thermal effect of cisplatin-crosslinked nanogels for triple therapies of ablation-chemo-embolization，第一位，Chemical Engineering Journal，2022，第一作（中科院一区，IF:16.74）

4)Li, Ling; Guo, Xiaopeng; Peng, Xiaole; Zhang, Hongsen; Liu, Yiming; Li, Han; He, Xiaojun; Shi, Dingwen; Xiong, Bin; Zhao, Yanbing; Zheng, Chuansheng; Yang, Xiangliang, Radiofrequency-responsive dual-valent gold nanoclusters for enhancing synergistic therapy of tumor ablation and artery embolization, Nano Today, 2020, 第一作(中科院一区，IF：20.72)

5)Wenjing Xie, Han Li, Houqiang Yu, Hongfu Zhou, Anran Guo, Qing Yao, Ling Zhang, Yongsheng Zhao, Hongan Tian and Ling Li. A thermosensitive Pickering gel emulsion with ahigh oil–water ratio for long-term X-ray imaging and permanent embolization of arteries. Nanoscale, 2022第一通讯作 (中科院二区，IF：8.3)

6)Hongfu Zhou, Wenjing Xie, Anran Guo, Bin Chen, Sanming Hu, Min Zheng, Houqiang Yu, Hongan Tian & Ling Li. Temperature sensitive nanogels for real-time imaging during transcatheter arterial embolization. Designed Monomers and Polymers, 2022第一通讯作 (中科院三区，IF：3.7)

7)Ling Li, Yiming Liu, Han Li, Xiaopeng Guo, Xiaojun He, Shinan Geng, Hao Zhao, Xiaole Peng, Dingwen Shi, Bin Xiong, Guofeng Zhou, Yanbing Zhao, Chuansheng Zheng, Xiangliang Yang. Rational design of temperature-sensitive blood-vesselembolic nanogels for improving hypoxic tumor microenvironment after transcatheter arterial embolization, Theranostics, 2018, 第一作 (中科院一区，IF：11.6)

8)Jian Zeng#, Ling Li#, Hongsen Zhang#, Jianye Li, Lingli Liu, Guofeng Zhou, Qing Du, Chuansheng Zheng, Xiangliang Yang. Radiopaque and uniform alginate microspheres loaded with tantalum nanoparticles for real-time imaging during transcatheter arterial embolization. Theranostics, 2018, 共同第一作 (中科院一区，IF：11.6)

9)Han Li#, Kun Qian#, Hongsen Zhang#, Ling Li#, Liangliang Yan, Shinan Geng, et al. Pickering Gel Emulsion of Lipiodol Stabilized by Hairy Nanogels for Intra-Artery Embolization Antitumor Therapy. Chemical Engineering Journal. 2021共同第一作（中科院一区，IF:16.74）.

10)Qing Du#; Ling Li#; Yiming Liu; Jian Zeng; Jianye Li; Chuansheng Zheng; Guofeng Zhou; Xiangliang Yang Fabrication of inherently radiopaque BaSO4@BaAlg, microspheres by a one-step electrospraying method for embolization Journal of Materials Chemistry B, 2018共同第一作 (中科院一区，IF：11.6)

11)Jun Xing,# Suijian Qi,# Zhengao Wang, Xin Yi, Zhengnan Zhou, Junqi Chen, Siqi Huang, Guoxin Tan, Dafu Chen(*); Peng Yu(*); Chengyun Ning(*). Antimicrobial Peptide Functionalized Conductive Nanowire Array Electrode as a Promising Candidate for Bacterial Environment Application, Adv. Funct. Mater., 2019, 29, 1806353. （JCR一区，IF 18.808，封面文章）

12)Xiao Huang,# Jun Xing,# Zhengao Wang, Jin Han, Renxian Wang, Changhao Li, Fang Lu, Jinxia Zhai, Zhengnan Zhou, Yangfan Li, Lei Zhou, Zhiguo Song, Dafu Chen(*), Peng Yu(*), Chengyun Ning(*), and Xieyuan Jiang. 0D/1D Heterojunction Implant with Electro-Mechanobiological Coupling Cues Promotes Osteogenesis. Adv. Funct. Mater., 2021, 2106249. （JCR一区，IF 18.808）

13)Zhekun Zhang, # Juning Xie, # Jun Xing, # Changhao Li, Tak Man Wong, Hui Yu, Yuanxing Li, Fabang Yang, Yu Tian, Huan Zhang, Wei Li, Chengyun Ning, Xiaolan Wang(*), Peng Yu(*), Light-programmable Nanocomposite Hydrogel for State-switchable Wound Healing Promotion and Bacterial Infection Elimination, ADV HEALTHC MATER, adhm.202201565（JCR一区，IF 11.092）

14)Jun Xing,# Qiyou Wang,# Tianrui He,# Zhengnan Zhou, Dafu Chen, Xin Yi, Zhengao Wang, Renxian Wang, Guoxin Tan, Peng Yu(*), and Chengyun Ning(*). Polydopamine - Assisted Immobilization of Copper Ions onto Hemodialysis Membranes for Antimicrobial. ACS Appl. Bio Mater., 2018, 1, 1236~1243. 

15)Xiao-Lei Miao＃,Hui-Min Ma＃,Qin-Hao Ke ,Shi-Yue Wang,Hong-Fu Zhou, Min Zheng. The determination of monosaccharide in different years Qingzhuan Dark Tea polysaccharide by liquid chromatography–mass spectrometry. Phytochemical Analysis.（SCI，JCR二区，IF3.373，Q2）

16)Ling Zhang1, Xiaolu Wang2, Jun Jiang2, Naian Xiao3, Jiayang Guo4, Kailong Zhuang, Ling Li, Houqiang Yu1, Tong Wu1, Duo. Chen5*. Automatic Interictal Epileptiform Discharge (IED) Detection Based on Convolutional Neural Network (CNN)[J]. Frontiers in Molecular Bioscience, 2022, 已接收.(SCI, IF3.5)

17)Peipei Gu1, Ting Wu2*, Mingyang Zou3†, Yijie Pan4,5*†, Jiayang Guo6*, Jianbing Xiahou7*, Xueping Peng8, Hailong Li9, Junxia Ma1and Ling Zhang3*. Multi-Head Self-Attention Model for Classification of Temporal Lobe Epilepsy Subtypes[J]. Frontiers in Physiology, 2020, 11(11):1-7.(SCI, IF4.755)

18)Ling Zhang, Xin Wang, Jinglu Zou, Yingxun Liu, Jinke Wang*. Effects of an 11-nm DMSA-coated iron nanoparticle on the gene expression profile of two human cell lines, THP-1 and HepG2. Journal of Nanobiotechnology, 2015, 13:3. (SCI, IF 9.429)

19)Ling Zhang, Xin Wang, Jinglu Zou, Yingxun Liu, Jinke Wang*. DMSA-coated iron oxide nanoparticle greatly affects the expression of genes coding cysteine-rich proteins by its DMSA coating. Chemical Research in Toxicology, 2015, 28(10):1961-1974.(SCI, IF3.973)